Introduction and Objectives: Almost 56 million deaths that occur in every year, in that 10.8% of peoples had died due to stroke. One in five women and one in six men affected by this illness called stroke in their lifetime. Stroke is the leading cause of mortality and disability. NLR and inflammatory marker can be used as a simple and easy marker for prognosis and mortality. The study aims to investigate the role of the NLR ratio in acute ischemic stroke Second foremost reason for death in the global is known as Stroke. Materials and Methods: Patients with features of acute ischemic stroke were subjected to a detailed history, examination and thorough investigations. The diagnosis was made by clinical history, neurologic examination and neuroimaging. The severity of stroke at the time of admission was classified based on the National Institute of Health Stroke Scale. Modified Ranking Scale used to determine the functional outcome at discharge. Results: Out of 68 patients enrolled in the study, 13 patients (19.1%) had a mild stroke, 45 patients (66%) were affected by moderate stroke, 6 patients (8.8%) had moderate to severe stroke, and 8 patients (5.9%) were severely affected. In the Chi-Square analysis for the association between NLR and MRS, the Pearson chi-square analysis shows significant results (P-value =0.000__ampersandsignlt;0.001) Conclusion: The duration of the hospital stay of the patient depends on NLR. The lifestyle of the patient and diet maintenance also affects the neutrophil and lymphocyte count of the blood (NLR).