Background: Abnormal posture leading to back pain is a major work-related health problem, especially in software and IT-enabled services. Objective: It is intended to find out the effect of Kinesio taping compared with rigid taping in alleviating pain and disability for work-related chronic low back pain in computer professionals. Method: Study was conducted on 26 computer professionals with chronic low back pain, divided into two groups randomly and intervened with Kinesio taping(KT) in one group and rigid taping(RT) in another group. The outcome of pain and disability was measured using the McGill pain questionnaire and the Oswestry disability index. Both groups were compared for the mean difference and effect size on pain and disability by using ANOVA and Cohen__ampersandsignrsquo;s. Results: statistical analysis showed that KT or RT useful in reducing symptoms but there was a significant difference of P __ampersandsignle;0.05 between the Kinesio tape group and the rigid tape group in terms of pain and disability. Conclusion: Kinesio taping was more effective than rigid taping in reducing pain and disability for computer users with chronic low back pain.