Coffee is the leading worldwide beverage besides water and its exchange surpasses US $10 billion worldwide. Controversies regarding its benefits and risks still exist as reliable evidence is becoming available supporting its health promoting potential; however, some researchers have shown concerns regarding the association of coffee consumption with cardiovascular complications. From a physiological perspective, the potential bioactivity originates from caffeine, the di-terpenes; cafestol and kahweol found in the oil, and the polyphenols, most remarkably chlorogenic acid. We shall sift through the existing information on coffee __ampersandsignamp; its bioactivity and also their link with and impact on the risk factors which are associated with heart disease such as lipids, blood pressure, inflammation, endothelial function, metabolic syndrome and potentially protective in vivo antioxidant activity. Numerous epidemiological studies have scrutinized the relationship between coffee drinking and Coronary Heart Disease as a healthy habit. Most prospective studies have not demonstrated a positive affiliation, though case-control studies in general have reported such an affiliation. This inconsistency could be clarified by an acute adverse effect of coffee, rather than a long-term adverse effect. We propose that coffee drinking may have an intense negative impact in activating coronary events in all age groups, and also post cardiovascular patients.