Introduction: Diabetes Mellitus is one of the most common metabolic disorders. Various pathogenic processes are involved in the growth of diabetes; insulin deficiency,insulin resistance. Oxidative stress can also play a role in the cause and pathophysiology of diabetes. Gamma-glutamyltransferase (GGT) has a pivotal role in the maintenance of intracellular antioxidant defences through its mediation of extracellular glutathione transport into most types of cells. Gamma-glutamyltransferase enzymatic activity may also be indicative of an early risk of inflammation. Aims and Objectives: To study the levels of Gamma-glutamyltransferase, FBS, HbA1c in type 2 diabetes patients. To find out correlations if any between the Gamma-glutamyltransferase Level with FBS, HbA1c. To evaluate GGT levels in controlled and uncontrolled cases of type 2 diabetic patients. Material and Methods: In this study, 100 study subjects with age above 40 years were divided into two groups - 50 patients having type 2 DM (the study group) and 50 healthy individuals (the control group). From the venous blood, serum gamma-glutamyltransferase was measured using a semi-auto analyser (ErbaChem 5 plus) using commercially available kits.FBS was measured by Erba XL (EM 360), HbA1c was measured by SD Biosensor. Ethical clearance was taken vide letter number 1397. Results: The mean value of GGT in the study group was 68.34 and in the control group it was 31.22 (p-value __ampersandsignlt;0.0001). There is a significant difference between serum gamma-glutamyltransferase values of the control group and the study group. Conclusion: There were increased levels of serum gamma-glutamyltransferase in patients with type 2 Diabetes Mellitus.