Background: Children routinely present with unsatisfactory oral hygiene due to a lack of interest in brushing twice daily. Motivation serves to be an integral part of health promotion to children at the learning phase of their life. Aim: The purpose of this study was to clinically evaluate and compare the efficacy of musical toothbrush over regular toothbrush in supragingival plaque removal among children of age 6-11years Materials and Methods: 42 children aged 6-11 years who fulfilled the criteria enrolled on a single-blind, randomized study. The Eligible subjects were randomly assigned into two groups by a second examiner one group used a musical toothbrush and another group used a regular toothbrush for the duration of the study. Subjects were instructed to brush their teeth at home twice daily for 2 minutes each day for the 45-day study period. At 0 day and after 15, 30 and 45days, the plaque was assessed following 24 hrs of no oral hygiene. At each visit plaque removal was evaluated using disclosing solution before and after subjects had brushed their teeth for 2 minutes under supervision. The plaque build-up was noted using the Quigley-Hein plaque index. Independent __ampersandsignlsquo;T__ampersandsignrsquo;test and paired T-test was used to compare the outcome variables within and across the two groups. Results: Greater mean changes in whole mouth plaque reduction were seen for Group 2 (musical group) when compared to that of Group 1(regular group) at days 15, 30 and 45 (P__ampersandsignlt;0.05). Conclusions: The present study showed significant improvements in supragingival plaque control in the musical brushing group. The features of the musical toothbrush compared with a regular toothbrush may increase motivation and compliance, thus helping to establish the habit of regular daily brushing of the teeth.