Introduction: LDL-C undergoes modification to form Oxidized LDL a crucial occurrence in the oxidation hypothesis of atherogenesis. Oxidized LDL and RLP-C stimulates the immune and inflammatory reactions and promotes atherosclerosis. Because of its lesser size along with high cholesterol content, and increased residence period in blood the remnant lipoproteins are highly atherogenic. Remnant lipoproteins enter into the arterial wall easily and taken up directly by macrophages lead to the formation of foam cells, thus initiating the lipid-laden plaque. Oxidized LDL along with remnant lipoprotein cholesterol and hs-CRP play a crucial role in the progression of coronary heart disease. Objective: The objective of the study is to measure the level of circulating Oxidized LDL and Remnant Lipoprotein Cholesterol associated with High-Sensitive C-Reactive Protein in Coronary Heart Disease Materials and Methods: This cross-sectional study was conducted on 91 CHD patient and 91 healthy control in the age group of 25 to 55 years and were age and sex-matched. After overnight fasting body fluid samples were collected for analysis for Lipid Profile, oxidized LDL and hs-CRP. ox-LDL and hs-CRP measured by ELISA method and Lipid Profile are measured using Auto Analyzer AU480. Results: The mean level of oxidized Low-Density Lipoprotein level in CHD was elevated (40.89__ampersandsignplusmn;8.69) and statistically significant (p-value __ampersandsignlt;0.001) compared to the normal healthy controls (16.6__ampersandsignplusmn;3.54). The mean RLP-C showed a significant increase (35.65__ampersandsignplusmn;16.11) in the CHD group when compared to controls (15.69__ampersandsignplusmn;12.15) (p __ampersandsignlt;0.001). hs-CRP level in CHD was (3.80__ampersandsignplusmn;1.35) and also shows a significant (p-value __ampersandsignlt;0.001) increase compared to the normal healthy controls (1.92__ampersandsignplusmn;0.47). Conclusion: Addition to conventional parameters, the estimation of ox-LDL, RLP-C and Hs-CRP can prove to be a valuable tool in risk assessment of population and management of the disease. Our results suggesting the link between the level of high ox-LDL along with remnant lipoprotein cholesterol and hs-CRP may consistent with atherogenesis in subject with CHD.