Introduction: Natural products are a significant source of synthetic and traditional herbal medicine and are the primary source of the health care system. The traditional medicinal methods, especially the utilization of medicinal plants play a vital role in covering the basic health requirements in developing countries. Objective: Henna is a traditional cosmetic agent used to stain hair, skin, and nails worldwide. Henna (Lawsonia inermis) is eminent of the Lythraceae__ampersandsignrsquo;s family that imparts a red-brown colour. Monetary, it is available in numerous types and colours e.g. dried leaves/ hair dye. Its mixture along with water is applied on body parts and hairs for few hours to obtain the colour. Methods: To make it economical and inexpensive, few chemical additives such as para-phenylenediamine have recently been mixed with henna. It achieves the same cosmetic effect in only 30 minutes but can cause severe adverse reactions. Paraphenylenediamine (PPD) has been mixed with natural henna to provide an ebony colour instead of the orange/reddish colour given by natural henna. Results: The other explanation behind adding p-phenylenediamine to the natural henna is to speed up the tattooing process, while natural henna staining takes 4 to 12 hours. The addition of PPD can help to reduce the time from an hour/ two for a longer-lasting effect as well. It has been observed to cause severe haemolytic anaemia and renal tubular necrosis in animals. Henna may cause haemolysis in patients with G6PD (glucose-6-phosphate dehydrogenase) enzyme deficiency in regions where it is commonly utilized. Conclusion: The principle behind this study is to understand the hazardous effects of adulterants mixed with Heena on the human body, either it is an immediate effect or a gradual effect on the body. Thus, Lawsonia Inermis can also work as a steady poison for an individual.