Introduction: Chronic suppurative otitis media is a long-standing infection of apart or whole of the middle ear cleft characterised by ear discharge. In conditions of Atticoantral type of pathology and cholesteatoma disease clearance from the middle ear cleft, mastoid antrum is done using modified radical mastoidectomy. Aim: This study aims to compare the mastoidectomy cavity obliteration with soft tissue graft and cartilage graft in canal wall down mastoidectomy. Methods: This prospective comparative study on mastoidectomy cavity obliteration with soft tissue graft in 20 patients (Group A) and cartilage graft in 20 patients (Group B) in canal wall down mastoidectomy surgeries conducted on patients diagnosed with chronic suppurative otitis media of atticoantral pathology. Postoperative outcome was compared between 2 groups. Results: The outcome showed that the patients obliterated with cartilage showed a faster rate of epithelialization and formation of the dry cavity when compared to patients obliterated with soft tissue with a statistically significant difference (Pvalue=0.003). There was a gradual decrease in ear discharge in Group A patients compared to Group B at the end of the third month with a significant statistical difference (Pvalue=0.046); however, there was no statistical difference by the end of the sixth month. There was no statistically significant difference in the postoperative hearing in terms of the Air-bone gap between the groups. Conclusion: From this study, we concluded that obliteration with cartilage provided much better results regarding the cavity__ampersandsignrsquo;s epithelialization, thereby forming dry ear at a faster rate both statistically and clinically, along with good anatomical configuration than soft tissues.