Introduction: Early detection of Right ventricular myocardial infarction is important because the time of onset of its hemodynamic effects is uncertain and the administration of intravenous fluid load can prevent these conditions from occurring. Aim: To study the occurrence, clinical profile and complication of right ventricular infarction in patients with acute inferior wall myocardial infarction. Methods: This study included 50 consecutive patients admitted to the Coronary Care Unit or General Medical Unit, Vinayaka Mission Medical College __ampersandsignamp; Hospital, Karaikal with a proven diagnosis of acute inferior wall infarction. Results: In 50 patients,49 patients had chest pain, 43 patients had sweated, 26 patients had vomiting, 8 patients had palpitation, 7 patients had syncope and 4 patients had breathlessness. Based on risk factors, 40 patients had smoking, 21 patients had alcoholism, 19 patients had hypertension, 12 patients had diabetes and 15 patients had dyslipidemia. Dependent on the clinical sign, 9 patients had pallor, 16 had bradycardia, 6 had tachycardia, 16 had hypotension, 16 had elevated JVP, 10 patients had S 3 on the right, and 2 had tender hepatomegaly. Conclusion: To conclude, the frequency of MI was higher with a prominent symptom in men and age 40 years older and a major risk factor in smoking and a higher mortality in right ventricular infarction patients.