Introduction: Diabetic Mellitus (DM) currently affects approximately 8.3 percent of the population in the United States and more than 79 million individuals are pre-diabetic. Of the many complications of DM, Diabetic foot ulcers (DFUs) remain a serious and challenging one to deal with. Many treatment modalities have been tried since time immemorial. As the technology and research have advanced, the treatment of DFUs has also seen many changes and the use of collagen dressings in DFUs remains one of them. Aims: Comparison between conventional dressings and collagen dressings in DFUs, to know the effectiveness of collagen dressing, its safety and effectiveness in controlling wound infection. Methodology: A prospective study was undertaken with 100 diabetic foot ulcer patients who presented to surgery OPD between 2018 and 2020. Out of the 100 patients, 50 patients were subjected to collagen dressings and 50 patients to conventional dressing. Results: Complete wound healing was seen in 42 (84%) out of 50 patients treated with collagen dressings while only 31 patients (62%) achieved complete wound healing when treated with conventional dressing. This reduced the need for skin grafting in patients treated with collagen dressings as compared to conventional dressings (16% vs 38%). Conclusion: Collagen dressing accelerates wound healing in patients with DFUs thereby reducing the duration of hospital stay and also decreases the need for split-thickness skin grafting. Through our research, we conclude that conventional dressings are better when compared to conventional dressings.