Background: Opioid dependency is among serious clinical and public health concerns in India. India has had an established pattern of use of an opioid group of drugs. Indeed, a sizable number of people in India use opioid drugs, suffer from opioid dependence and seek treatment for the same. The most common treatment strategy for opioid dependence is opioid substitution therapy (OST). Another regimen used for substance dependents is Dialectical behaviour therapy (DBT). It is said to incorporate concepts and modalities which are designed to promote abstinence and thereafter reduce the length of consumption and also the adverse impact of relapses. Case Presentation: This case study is about AB, a 23-years old male who sought care for opium dependence. His chief complaints were inability to cut down the use of the substance (opium paste), experiencing withdrawal symptoms, low mood, low self-confidence and increased craving for the substance. Psychological Assessment that was done comprised of Severity of dependence scale (SDS), Brief-Cope Questionnaire, Emotional Regulation Questionnaire (ERQ) and Interpersonal Competence Questionnaire-15 (ICQ-15). Subsequently, TAU along with DBT techniques was applied over two months (13 sessions) and showed significant improvement in the patient. The outcome of the intervention showed a decline in independence levels, increased distress tolerance, better emotional regulation and interpersonal relationships. The patient eventually demonstrated decreased drug usage and improved skilful behaviour. Conclusion: Thus, it can be concluded that DBT is effective along with pharmacology therapy to promote and enhance the holistic well-being of the patient with opioid dependence. This gives an example of how trainee treatment can be used not only to decrease opioid dependency level but also to increase distress tolerance, better emotional regulation and interpersonal effectiveness in relationships.