Objective: We evaluated biogenic synthesized nanoparticle (NPs) from plant extracts and their role was studied in Solanum Lycopersicum. Background: Several disease-causing organisms (pathogens) can infect Solanum Lycopersicum(Tomato). The most common diseases that affect tomatoes are caused by various fungi, bacteria, and viruses. The utility of plant extracts for NPs synthesis has various advantages such as accessibility and safety when handling. Methods: We review bacterial diseases of tomatoes, the role of medicinal plants to control diseases. The study also includes the green synthesis of NPs and their application to control phytopathogens in Solanum Lycopersicum. Results: This review critically assesses the role of medicinal extracts synthesized different NPs to control phytopathogens in tomato, application of NPs in tomato plant disease, antimicrobial studies in detail. Conclusion: The need for environmental non-toxic synthetic protocols for NPs synthesis leads to the developing interest in biological approaches that are free from the use of toxic chemicals as by-products. Hence, there is an increasing demand for green nanotechnology. We discussed the role of many medicinal plant extracts to control phytopathogens and their applications in tomatoes.