Introduction: Ganglions are one of the commonest soft tissue lesions that arise from a joint capsule or tendon sheath. The gold standard treatment for this is excision biopsy. The other options are intra-lesional hyaluronidase injection or triamcinolone injection after aspiration. These techniques have drawbacks. Surgery has a formation of scar which sometimes has a chance of becoming an unsightly hypertrophic scar. Aim: To check the effectiveness of Platelet Rich Plasma (PRP) in dorsal wrist ganglion. Materials and Methods: A case-control study in adherence with the principles of the Declaration of Helsinki was conducted on 60 patients. 20 patients were given intra-lesional hyaluronidase injection after aspiration and 20 patients were given intralesional PRP injection after aspiration and another 20 patients were given triamcinolone injection after aspiration. Results: PRP group had lower recurrence rates compared to the other two groups. The Hyaluronidase group had recurrences and required a repeat injection, it was also noted that the capsule thickened after the treatment in these patients. Triamcinolone group had lower recurrence rates at 1 month follow up but this eventually increased over a 6 monthly follow up, they also required a second injection Conclusion: PRP is easy to obtain, safe and cost-effective in the management of dorsal wrist ganglion. More studies to be conducted in the future in a larger population with a larger observational period to confirm this.