Background: The treatment of open apices in non-vital permanent teeth is done with apexification using various materials like MTA, Biodentine and other materials. This study aimed to assess the utilization of Biodentine in apexification and large periapical lesions. Material and Methods: A male patient with the chief complaint of pain and pus discharge in the upper front tooth region. Initially, the patient was asymptomatic but eventually developed periodic swelling. On intraoral examination, it revealed the presence of porcelain fused to the metal crown in the right maxillary central and lateral incisor along with a sinus tract in the periapical region. During percussion of the tooth, it manifests positive tenderness. On radiographic examination, it shows that the root canal was incompletely obturated in both the incisors with incomplete root formation seen in the central incisor. The treatment protocol for tooth 11 and 12 was to perform root canal treatment along with apical plug formation using Biodentine. Therefore, under rubber dam access cavity was prepared and biomechanical preparation was done along with standard disinfection protocol using activation method and given intracanal medicaments. After 2-3 sittings of medicament, the apical plug formation was done in 11 along with filling of rest of the root canal with resin material. Results: In this case report the appreciating healing was seen at 3 months and 1 year follow up. Conclusion: The non-surgical conservative approach used in this case seems to be highly effective and gave astonishing results with complete healing of periapical lesion in central incisors