Introduction: Rheumatoid Arthritis (RA) is a chronic inflammatory disease principally involving the joints, which is autoimmune. However, osteoarthritis is a degenerative disorder commonly affecting large joints. They not only differ clinically but histologically as well. This study entails the comparison and grading of histopathological features of synovial biopsies of patients suffering from these diseases using a pre-established grading system. Aims: To Compare and analyse histopathological features of synovial biopsies of patients suffering from Rheumatoid Arthritis and osteoarthritis. Methodology: 31 synovial biopsy specimens each, of rheumatoid arthritis and osteoarthritis respectively, were reviewed from the institute__ampersandsignrsquo;s case files. The histopathological features were analyzed and a diagnostic criterion was set using a grading system involving seven histological features to differentiate the same. Results: It was observed that all the RA specimens scored a total score of 11 or more. Whereas, out of the 31 OA specimens, all had scored less than 11 points. Conclusion: It was established that a total score of 11 points (maximum 20 points) for RA synovitis biopsies can confirm a histopological diagnosis of RA synovitis. This analysis helped better the understanding of histopathology and compare the histologic variation present in synovial membrane tissue in patients suffering from rheumatoid arthritis and osteoarthritis.