Introduction: Creatine is one of the widely researched nutritional supplements which increases intramuscular creatine and helps to improve training adaptations. Creatine supplement with resistance exercise also increases fat-free mass. Literature evaluating the efficacy and safety of creatine in the Indian population is sparse. Aim: To study the efficacy and safety of creatine in improving muscle mass and strength in resistance-trained individuals. Methodology: In this prospective, study, healthy young male (18-25 years) received a regular diet and exercise program (Control group) or creatine monohydrate 20 gm/day for seven days and five gram/day for the next three weeks along with designed exercise program (Creatine group). Parameters for strength, body composition and body circumference measurements were recorded. Results: Thirty participants were included. In the creatine group, the difference in the weight from baseline to day seven was significant (62.19+5.57 vs 63.28+5.49 kg; p__ampersandsignlt;0.0001). The weight of participants in the creatine group increased from 62.19+5.57 kg at baseline to 63.28+5.49 kg and 65.14+5.40 kg after seven day and four weeks respectively (p__ampersandsignlt;0.0001). Performance in bench press test significantly increased in creatine group after seven days [64.0+9.14 vs 69.83+9.60 Kg (1 RM); p__ampersandsignlt;0.0001]. Change in the arm girth (p=0.0263), thigh girth (p=0.0003) and calf girth (p=0.0003) in the creatine group were significant over some time. No adverse events were reported in either group. Creatine was well tolerated by study participants without any adverse event. Conclusion: Our results suggest that creatine may be effective and well-tolerated in improving muscle mass and strength in resistance-trained healthy adults.