Aims and Objectives: The research work presented here aims to develop a novel approach towards a precise and effective analytical method for qualitative estimation of methscopolamine bromide, a drug of choice to treat peptic ulcer. Methods: The absorbance of methscopolamine bromide was low even at a higher concentration as obtained from the Ultraviolet visible (U.V.) spectroscopical method. Therefore it was required to enhance absorbance value to precisely perform qualitative analysis by different approaches. In this process, novel attempts were made to develop a new method for estimation such as the addition of chromophores and the use of colourimetric techniques but all of the attempts did not produce satisfactory results. Results: At last encouraging results including enhanced absorbance were obtained by using sodium picrate at __ampersandsignlambda;max of 440 nm and linearity was observed within the range of 1-5 __ampersandsignmu;g/ml with a regression coefficient of 0.984. The method was then validated to ensure reproducibility as per ICH (International Conference on Harmonization) guidelines. Conclusion: The method was successfully employed for the determination of methscopolamine bromide with good linearity, precision, robustness and specificity. The proposed method can be used for quality control during the routine quality assessment of bulk drug and does not involve the use of residual solvents which ensures that the method is novel and economic which may be used by pharmaceutical industries for commercial utilization.