Background: __ampersandsignlsquo;Leucorrhoea__ampersandsignrsquo;, a fairly common gynaecological issue, is an abnormal vaginal discharge often associated with ir ritation and is non-hemorrhagic. The objectives to investigate the various causes of leucorrhea among reproductive-age women. METHODS: The present study was conducted on 250 patients of adult female patients of the reproductive age group (aged 18 years to 45 years), clinically presenting with complaints of leucorrhoea during the period from October 2018 to December 2019 in the OPD Saraswathi In stitute of Medical Sciences in Hapur, Uttar Pradesh. The PAP smear findings to establish the profile of the causative organism, presence of microorganisms done by wet mount, Gram staining and KOH mount and identify the bacterial and fungal pathogens of the indicated cases by culture identification. Results: Age-wise distribution showed most common in the age group of 26-30 years, type of discharge thin mucoid in (72.8%), followed by thick curdy discharge in (16.8%).On PAP smear subjects were Negative for intraepithelial lesion or malignancy (NILM) (88%), a minor proportion of subjects (0.8%) had a high-grade squamous intraepithelial lesion (HSIL), Atypical squamous cells-cannot exclude HSIL (ASC-H) (0.8%), and squamous cell carcinoma (0.8%). The majority of females (34%) were seen to have S. aureus as observed on the bacterial culture of leucorrhoea secretions and fungal culture majority of females (27.2%) were seen to have the presence of C. Albicans. Conclusion: A significant association of leucorrhoea with socio-demographic factors, clinical features, PAP smear, bacterial as well as fungal culture in the present study emphasizes the need for health education and preventive practices related to personal __ampersandsignamp; menstrual hygiene __ampersandsignamp; family planning practices in females.