Introduction: Animation is about creativity, movement, and imagination. It offers the opportunity to bring an object, drawing or person to life. The creative process of animation has been adapted to provide a clinically effective framework to complement evidence-based therapeutic practice. Using simple techniques, this approach has been designed to facilitate motivation with difficult-to-reach clients. With the flexibility to work with verbal, non-verbal materials animation enables the service user to express thoughts and feelings using visual, tactile, and auditory techniques. Aim: To identify high functioning autism children using the High-Functioning Autism Spectrum Screening Questionnaire (ASSQ). To review the effect of animation therapy for improving social skills, communication, and self-confidence in an experimental group of youngsters with an autism spectrum disorder. Method: The study was done on 40 subjects, 20 in the control group and 20 in the experimental group. The screening for top functioning autism clients was done using the High-Functioning Autism Spectrum Screening Questionnaire (ASSQ). The pre-test and post-test were done using the Gilliam Autism Rating Scale (GARS-2). The scores of both groups were compared to find out the effectiveness. Result: Statistical analysis shows there is a statistically important distinction in the social interaction of youngsters. Conclusion: This study concludes that animation medical care is simpler in up social interaction in kids with syndrome Autism Spectrum Disorder.