Background: Covid-19 pandemic has over 79 million cases and 1.7 million deaths globally till the last week of December 2020. Its high burden is a great concern for the entire world. The pandemic has placed extraordinary levels of physical risk __ampersandsignamp; psycho-logical stress on health care (HCW) workers. Addressing HCW knowledge, attitude __ampersandsignamp; practice is very crucial in managing the covid-19 outbreak. Objective: Explore knowledge, attitude __ampersandsignamp; practice about Covid-19 among HCW of a tribal district in central India. Methods: This is hospital-based cross-sectional study. 125 participants were included following convenient sampling and a self-developed questionnaire was used to collect data regarding knowledge, attitude __ampersandsignamp; practice of newly appointed HCW in a tertiary care hospital in Raigarh which is a tribal district of Chhattisgarh. Knowledge, Attitude and practice score calculated and tested with socio-demographic variables. Results: Proportion of adequate knowledge, positive attitude and good practice among participants were 41%,75% __ampersandsignamp; 84% respectively. We found higher knowledge score for age (9+3.49 __ampersandsignamp; 8+3.06 ), family type (8.63__ampersandsignplusmn;3.47 __ampersandsignamp; 7.82__ampersandsignplusmn;2.57), work sector (8.55__ampersandsignplusmn;3.41 __ampersandsignamp; 7.68__ampersandsignplusmn;2.24), education (9.09+3.61 __ampersandsignamp; 6.33+2.06 ), profession (9.04+3.32 __ampersandsignamp; 7.35+ 3.38 ) and specific work (9.33+3.28 __ampersandsignamp; 7.86+2.93) in covid-19. 71% Doctors __ampersandsignamp; nurses have positive attitude comparing to 29% among nurses which is significant (p=0.04). Conclusion: HCW must be motivated by authorities to acquire adequate knowledge, a positive attitude and good practices. Knowledge attitude and practice of the health care workers is crucial in fighting the Covid-19 outbreak and authorities can empower health care workers with updated knowledge which in turn will improve their attitude and practice