Background: The COVID-19 epidemic has undoubtedly affected the working conditions of large segments of society. More specifically, a growing body of studies has raised the possibility that precautionary measures and closures, as a result of, the COVID-19 crisis could affect women and men working in different ways, mostly due to the traditional division of domestic work between the genders in Saudi society. Objective: In this study, we are trying to explore how the impact of the closure epidemic on domestic responsibilities and the work from home on men and women. Methods: The researchers developed a questionnaire to identify the impact of the closure on childcare, domestic chores, and the work environment within the home, and applied it to 370 faculty members and teachers, with an average age of (38.5__ampersandsignplusmn;9.6). Results: The results indicated that there were statistically significant differences between men and women in childcare and domestic chores, which affected in favour of women. Additionally, the results indicated that the sample of students with children was significantly affected during the lockdown compared to peers without children. However, there were no differences between the faculty staff and the teachers on the dimensions of the questionnaire. In addition, there were no differences in the level of age over the questionnaire dimensions between them. Conclusion: Based on these results, the study recommended the importance of urging university officials and the Department of Education to provide a range of rescue and stimulus packages, including support to faculty members and female teachers by providing flexible working hours after the epidemic, part-time work arrangements, telecommuting, support during pregnancy, and parenting. In addition, they should take into account the disparity between women and men in domestic responsibilities when evaluating for scientific promotion or managerial positions.