Introduction: The pandemic COVID-19 is an important global threat because of its high infectivity and case fatality rate in high-risk patients. The studies related to physiological mechanisms, pathogenesis, effective laboratory diagnostic methods are still in investigative stages. Several studies on COVID-19 report that inflammatory reactions play a vital role in disease progression. Objective: In this study, we evaluated the association between the C-Reactive Protein (CRP) and the severity of COVID-19 pneumonia. This study would help the clinicians to monitor the prognosis and severity of the disease. Methods: A Retrospective study conducted in the Department of Microbiology over 3 months with 336 laboratories confirmed Corona positive patients. Blood samples were collected from these patients and CRP was estimated by the Latex Agglutination test. Results: Of the 336 patients, 142 (42.2) showed positive results for CRP. Among CRP positive cases, 67 showed high CRP(__ampersandsigngt;24mg/L) and 75 showed low CRP(__ampersandsignle;24mg/L). High CRP was found to be associated with increased severity of the illness. Conclusion: CRP may be a marker of disease severity and may be a valuable indicator for determining the severity of patients with COVID-19. Continuous CRP monitoring may also predict the prognosis of cases. Further investigations are required to demonstrate the mechanisms by which increased CRP is seen in patients suffering from SARS- CoV-2.