Introduction: During this COVID-19 pandemic, post-graduate trainees being pillars of the healthcare system are subjected to a greater risk of acquiring the infection during their duty hours. It was warranted to assess their attitude and COVID-19 preparedness. Methods: A cross-sectional survey was carried out among the working post-graduate trainees in ShyamShah Medical College and associated hospitals at Rewa, Madhya Pradesh, India in the month of September 2020. A self-administered, anonymous questionnaire comprising of 30 close-ended questions was circulated to gather the relevant information. A total of 200 PG students submitted their responses, out of which 111 complete responses were included in the statistical analysis. Results: Male: female participant ratio was 1.13:1. A total of 72% of participants knew their present COVID-19 status, whether positive (n=13) or negative (n=67). 4 of them were suffering from chronic diseases like asthma. 30-41% of them were taking COVID-19 prophylaxis like hydroxychloroquine (HCQ), vitamin-C, zinc, ayurvedic medicine etc. All participants who were COV ID-19 positive thought that they were not well prepared against the virus during their duty hours while 44.1% of participants were anxious about the disease. A significant number of participants (91%) believed that even with all the preparedness it (Corona) may happen to anyone. Conclusion: In the present study, less than 6% of postgraduate trainees were found to have a positive attitude and satisfactory preparedness for self-protection during this critical period.