Objective: To describe the clinical and laboratory profiles of paediatric (Human Immunodeficiency virus) HIV admissions and their outcomes post scale up era. Method: Information on the clinical profiles, immunology and outcome was obtained from the case notes of HIV infected children admitted between the year 2007 and 2010 at a Nigerian teaching hospital. Data was analyzed with the SPSS 18 software. Results: Of the 2523 paediatric admissions 42(1.7%) were HIV infected. The 42 were made up of 21 boys and 21 girls and their mean age was 3.7__ampersandsignplusmn;2.9years. Pneumonia, septicaemia, Tuberculosis, malaria, meningitis, otitis media, osteomyelits, pharygotonsilitis and septic arthritis was the diagnosis in 10(23.8%), 10(23.8%), 10(23.8%), 7(16.7%), 1(2.4%), 1(2.4%), 1(2.4%), 1(2.4%) and 1(2.4%) children respectively. Sequelae followed all neurological and bone infections. Of the total 191 childhood deaths recorded on the paediatric wards 9(4.7%) were due to HIV. A case fatality rate of 9(21.4%) was recorded. Tuberculosis, septicaemia, bacterial pneumonia and immune reconstitution syndrome accounted for more than 60% of the deaths. Ten patients were on Highly Active Anti-retroviral Therapy (HAART) while the remaining 32 were not. No deaths were recorded among the patients on HAART in contrast to the 9 deaths amongst patients not on HAART (p = 0.04, OR = 1.41 CI= 1.12 __ampersandsignndash; 1.77). Four of the 5 patients on HAART had sequelae compared with the single case of sequela amongst the 30 not on HAART (p__ampersandsignlt;0.01, OR=0.07, CI= 0.01 __ampersandsignndash; 0.71)__ampersandsignnbsp; Conclusion: Human Immunodeficiency Virus infection is an important cause of morbidity and mortality in childhood. Super imposed bacterial infections are important reasons for admissions. Bone and neurologic infections are commonly associated with sequelae amongst survivors. Administration of HAART was protective against mortality.