Background: The golden hour that refers to the first hour after trauma determines the fate of the RTA victims to a large extent. When a patient does not receive first aid immediately, it affects their condition to a large extent, mostly their quality of life that eventually results in death. As future healthcare professionals, the ability to render first aid services is the need of the hour. With the increasing mortality of accidents and trauma, proper provision of first aid as the first line of treatment can help save lives. Objective: To assess the knowledge and attitude of first aid skills among medical, dental and nursing students in the time of the COVID-19 pandemic. Methods: This was a cross-sectional questionnaire-based study conducted for three months that included 300 undergraduate medical, dental and nursing students in Bhubaneswar city, Odisha. A self-structured 21 item questionnaire regarding first aid skills was used to assess the knowledge and attitude of the students. Data were entered in a Microsoft excel sheet and analysis was done using SPSS version 25. Results: It was found that 65.1% of the medical students were aware regarding first aid skills. Statistically significant differences were observed among the groups (Dental, Medical and Nursing) for the responses of the questionnaire. A moderate correlation was seen between the knowledge of first aid and individual knowledge levels. Conclusion: This study identified the need for introducing formal first aid training classes for medical, dental and nursing stu dents and brought out the key areas in which first aid knowledge was lacking.