Background: With the unprecedented outbreak of COVID19, there has been a significant rise in patients and deaths all over the world. Nursing professionals play an essential role in providing health services, promoting health and preventing diseases. Favourable knowledge and practice among them regarding the disease are essential to winning this battle of COVID 19. Objective: To assess knowledge, and perception of student nurses of different colleges of Odisha towards COVID19. Methods: An online survey was conducted among nursing students to collect information regarding COVID 19. It was a pre-designed, structured questionnaire prepared by the objectives. Ethical approval from IEC was obtained along with permission from the head of the institutions of the participating institutions. Results: More than 90% of participants had correct knowledge regarding mode of transmission, common symptoms and preventive strategy. They had limited knowledge (79.8%) on people with a high risk of complications or fatal disease whereas knowledge regarding correct incubation period, complications and method of dead bodies disposal was poor(__ampersandsignlt;60%). Most of them had favourable perception regarding sharing travel history with health professionals (94.5%), hand washing (95.3%). There was poor perception regarding the fatality of COVID 19 and quarantine of cases. Conclusion: The nursing students had good knowledge regarding disease and preventive strategy but limited knowledge on predicting complications or fatal disease and method of disposal of dead bodies. The perception of the nursing students was favourable in most of the aspect but had poor perception regarding a few.