Introduction: Hepatic disease stand as one of the foremost health troubles worldwide with liver cirrhosis and drug-induced liver injury accounting 9th leading cause of death in western and developing countries. Objective: Hepatoprotective activity of the aerial part of Boerhavia repens was investigated against the carbon tetrachloride induced hepatotoxicity model in Wistar albino mice. Methods: The acute toxicity study of the selected plant showed that there is no mortality or adverse reaction at the fixed dose of 2000 mg/kg. The methanolic extract at 200 and 400 mg/kg body weight respectively were administered daily to study the Hepatoprotective effect in the carbon tetrachloride-induced hepatotoxic model for 7 days. It was observed that there was a remarkable decrease in bilirubin, ALP, SGOT and SGPT levels in the treatment group as compared to the hepatotoxic group. In a histopathological study, hepatocytic necrosis and inflammation in the centrilobular region with portal triaditis was found in the hepatotoxicity induced group where as minimal inflammation with moderate portal triaditis and normal lobular architecture observed in extract treated groups. At the end of the experiment, Liver and blood samples were collected for biochemical meas urements. Parameters measured were GSH, GPx, GR, GST, SOD, MOD. Results: Results showed that methanol extract scavenged free radicals. Results of in-vivo experiments showed that the metha nol extracts inhibited lipid peroxidation, protected the experimental animals from hepatic toxicity, and maintained the levels of antioxidants in a dose-dependent manner. Conclusion: From the observation, it can be concluded that the methanolic extract of Boerhavia repens has the potential to revert the hepatic injury induced by carbon tetrachloride. Comparatively, the methanolic extract at 400 mg/kg w/w resulted in a significant Hepatoprotective effect. The standard drug silymarin was used for comparison.