Background: Varicose vein is a saccular, tortuous, dilated vein of lower limb invariably associated with local valvular incompetency. They not only can cause cosmetic problems but also can cause clinical symptoms such as pain and heaviness in the lower limb. It is most often associated with occupations requiring prolong orthostasis like teachers nursing staff, shopkeepers etc. In spite of this strong relationship with occupations requiring prolonged orthostasis, epidemiological studies on working population are limited. We conducted this study to identify the occupational and demographic risk factors of lower limb varicose vein which could be interventional in improving working atmosphere and quality of life for their long term nursing career. Method: It was a cross sectional study conducted from February 2015 to March 2015 Data was collected through a self-filled preformed questionnaire from 364 nurses working at GMCH and Associated Hospitalsin Udaipur, Rajasthan. The nurses having lower limb VV were subject to clinical examination by the experts for confirmation of the diagnosis. Results: A total of 364 nurses participated in the survey and 88 (24.17%) had lower limb VV. The female nurses had slightly higher prevalencecompared with their male counterpart (24.50% V/S 22.58%). The occupational risk factors responsible for lower limb VV among nurses were longer work history (40.42% P- 0.001) longer working hours (__ampersandsigngt;8 hrs 38.70%, p- __ampersandsignlt;0.001) and prolonged orthostasis (standing longer __ampersandsignndash; 57.14%) beside patients bed. They are older in age (28.30%, p- 0.001) and also having a family history of VV (38.70%, p- 0.006) Conclusion: In nurses older age, family history, longer work history, longer working hours and prolonged standing beside patient bed are major risk factors for developing lower limb varicose vein.