Introduction: Microorganisms have a pivotal role in the induction and continuing of pulp and periapical pathosis. Objectives: To evaluate antifungal efficacy of commonly used endodontic irrigating solutions on reducing the CFU count of C Albicans in extracted human permanent teeth. Methods: The research question was formulated using the PICO strategy. A planned literature search was conducted by two personnel independently using MEDLINE, PubMed, EBSCO, Scopus, Google Scholar and manual search using College library. Resources were searched from 1st Sept 2009 to 31st August 2019 to identify appropriate studies. Inclusion and exclusion criteria were implicated to select articles. All cross-references lists were also selected. A systematic data extraction sheet was formulated. Results: A total of 101 articles were identified through the data base.13 articles were selected after thoroughly reading full texts and were assessed for eligibility. After going through these 13 articles, it came to notice that no endodontic irrigant has 100% antifungal properties. In many studies, it is evident that out of different concentrations of Sodium hypochlorite, 5.25% concentrated solution showed the best results. Conclusion: From this systematic review it can be concluded that although the antifungal activity of various endodontic irrigating solutions is checked by various authors, no single irrigant proves to be completely successful in reducing the count of candida.