Introduction: Candiduria in catheter-associated urinary tract infection (CAUTI) is most challenging because of the emergence of extreme drug-resistant infections especially in critically ill patients of medicine Intensive Care Unit (MICU) in a tribal-dominated rural tertiary care centre. Objective: The study aims to find out the incidence, risk factors and their impact on candiduria in CAUTI in the tribal-dominated rural tertiary care centre. Methods: This prospective study was conducted in MICU of SLNMCH, Koraput(Odisha) from March 2019 to February 2020. It included confirmed cases of CAUTI, diagnosed as per standard Centre__ampersandsignrsquo;s for Disease Control National nosocomial infection and diagnosed cases of candiduria. Demographic and clinical data of these patients were collected. Under all aseptic conditions, urine was collected transurethral and sent for microscopy and culture and sensitivity to the microbiology laboratory. Results: In our study, the incidence of candiduria in CAUTI was 19.5%.These cases were more common in the tribal population (88.9%), female gender(75%), age more than 40 years and up to 60 years(62.5 %), duration of the catheter up to 7 days(62.5%), low socioeconomic status(62.5%) Staphylococcus aureus being the commonest associated microorganism(37.5%), followed by E coli(25%) and type 2 diabetes mellitus(50 %) being the most common morbidity. Conclusion: Our analysis precisely of this Tribal population, brings several important and unique findings(risk factors of multi-organ involvement) than other study and population, which will modify or add in the development of some new or update guidelines that might help critical care physicians in dealing with these patients on multiple organs support, and reduce morbidity, mortality in the ICU.