Introduction: Metabolic Syndrome (MS) is a group of disorders including abdominal obesity, glucose intolerance or insulin resistance, dyslipidemia, hypertension, lipid peroxidation, and pro-inflammatory states. Solasodine and Coenzyme Q10 are acknowledged as potent antioxidants that prevented oxidative stress; a critical risk factor for the progression of MS. Objective: To evaluate the potency of solasodine with coenzyme Q10 on high fat diet-induced metabolic syndrome in rats by modulating adipokines and lipid peroxidation. Methods: Out of six groups (n=6), one group as a control (normal) received a standard diet for 16 weeks, and the other five groups were administered with a high-fat diet (HFD) only or with pioglitazone, coenzyme Q10, Solasodine and Solasodine with coenzyme Q10, (SDQ10) for the last 4 weeks. Results: Animals feeding with HFD for 16 weeks exhibited a significant increase in body weight, total cholesterol, triglyceride, and a decrease in HDL-cholesterol as well as developed glucose intolerance. It also raised lipid peroxidation and leptin level as well as lowered reduced glutathione and adiponectin level. Treatment with a combination of solasodine and coenzyme Q10 effectively reversed the above paradigm of metabolic syndrome induced by a high-fat diet. Besides, treatment with SDQ10 reduced the lipid peroxidation and enhanced the reduced glutathione as well as normalized the levels of leptin and adiponectin. Conclusion: The combined supplementation of solasodine and coenzyme Q10 reversed the effect of HFD intake on lipid peroxidation and adipocytokine levels and improve the symptoms of metabolic syndromeA