Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a common, preventable and treatable disease that is characterized by persistent respiratory symptoms and airflow limitation that is due to airway and/or alveolar abnormalities usually caused by significant exposure to noxious particles or gases. The chronic airflow limitation that is characteristic of COPD is caused by a mixture of small airways disease (e.g. Obstructive bronchiolitis) and parenchymal destruction (emphysema), the relative contributions of which vary from person to person. 1 Objective: The present study aims to investigate whether an increased concentration of high sensitivity (hs) CRP is related to the degree of lung function impairment, systemic inflammation, body composition, exercise capacity, and quality of life in patients with advanced COPD. Methods: A cross-sectional study was conducted in the Department of Medicine of LLRM Medical College and Associated SVBP Hospital Meerut in 2019-2020. Sixty-one Patients with Chronic Obstructive Pulmonary Disease of age 35 years and above undergoing treatment Meerut were included in this study. Each subject has undergone a thorough workup for history and physical examination to fulfil the inclusion __ampersandsignamp; exclusion criteria, Routine Hematological __ampersandsignamp; Biochemical Investigations were carried out. Results: Mean age of the patients was 56.16 years. Most of the patients were in the age group 56-65 (44.26%). The majority fell in the range of 36-65 years (85.24%). The majority of the patients were males (77.05%). Females were few 14 (22.95%). The hsCRP levels correlated negatively with FEV1 (p-0.000) and 6-minute walking distance (p-0.000). Correlation between hsCRP levels and BMI was also negative though not significant (p-0.32). BODE index and hsCRP levels had a highly significant positive correlation (p-0.000). Conclusion: High sensitivity C-reactive protein levels correlated significantly with functional ability parameters in chronic obstructive pulmonary disease patients. There was a significant correlation with forced expiratory volume in 1 second, exercise capacity assessed by six-minute walking distance test and, Body-mass index, airflow Obstruction, Dyspnea, and Exercise( BODE index). However, the levels did not correlate significantly with body mass index.