Introduction: Postoperative nausea and vomiting (PONV) are one of the major concerns for patients undergoing laparoscopic surgeries. There is conflicting evidence that whether perioperative intravenous dextrose reduces PONV. Objective: To establish the role of dextrose in preventing PONV after laparoscopy. Methods: A prospective double-blind study was conducted with 60 non __ampersandsignndash; diabetic, non-smoker, ASA-I female patients, 18 __ampersandsignndash; 60 years of age posted for laparoscopic surgeries (LS) under general anaesthesia (GA). All patients were randomized into 2 groups: Group __ampersandsignndash; D received 5% Dextrose @ 125 ml/hour and Group __ampersandsignndash; N received 0.9% Normal Saline solution@ 125 ml/hour for 2 hours, beginning with the start of surgical closure. PONV scores, hemodynamic parameters, total rescue antiemetic and analgesic consumption were noted in the first 24 hours. Results: Out of 60 patients, Group D, 11(36.7%) patients and Group-N, 19(63.3%) patients need rescue antiemetic. The inci dence of PONV was most significant on admission to PACU (p = 0.0388). The overall incidence of PONV was reduced by 26.9% in Group D which was significantly less compared to Group N (P= 0.0029). No statistically significant difference in terms of de mographic characteristics, mean duration of surgery, difference of mean capillary blood glucose (CBG) level and requirement of rescue analgesia were noted among 2 groups. Conclusion: Perioperative administration of 5% dextrose reduces the incidence of PONV and consumption of antiemetics in patients undergoing LS under GA.