Background: Leprosy is a chronic, gradually progressive, granulomatous disease caused by Mycobacterium Leprae. Leprosy is difficult to diagnose due to its clinical heterogeneity and histopathological examination and sub-classification play an important diagnostic tool for the management of the cases. Objective: To study the various histomorphological spectrum of Leprosy in skin biopsies and document various patterns of diseases in the tertiary care hospital. Methods: Prospective study of 43 skin biopsy specimens suspicious of Hansen__ampersandsignrsquo;s received in histopathology laboratory. Biopsies were immediately fixed in 10% buffered formalin and stained with both haematoxylin __ampersandsignamp; eosin, and Fite Faracoon. All sections were reviewed and classified according to Ridley__ampersandsignndash;Jopling classification. Clinical details of the patient were obtained like, age, sex, site, and type of lesions were obtained and clinicopathological correlation was done. Results: Out of 43 cases studied 32.5% cases showed features of Borderline Tuberculoid (BT) type of Leprosy which was the most common histological subtype, 23.2% cases showed histology of Borderlinelepromatous (BL) Leprosy, 11.6% cases were borderline (BB) case 9.3%cases demonstrated the features of Lepromatous leprosy (LL), 6.9% cases displayed Tuberculoid lep rosy (TT), 4.6% cases were of Histoid Leprosy (HL), and 11.6% cases were reported as Indeterminate leprosy (IL). Fite Faraco stain showed positive in 28% of cases. The clinicopathological correlation was seen in 62.7% of cases studied. The disease was most common in the middle age group and was detected in the males frequently. Conclusion: Histopathological study of leprosy is very important in understanding the disease, its varied manifestation, and complications. For the correct and adequate treatment, the diagnosis must be made early and it should be accurate.