Introduction: Musa acuminata, Musaceae, popularly known as __ampersandsignlsquo;banana__ampersandsignrsquo;, is a perennial tree-like herb cultivated in many tropi cal and subtropical regions around the world. Banana, eaten as a fruit or a vegetable, is one of the most important crops in several countries due to its enriched food and versatile medicinal value Plant contains apigenin glycosides, myricetin glycoside, myricetin-3-O-rutinoside, delphinidin, pelargonidin, peonidin, and malvidin. naringenin glycosides, kaempferol-3-Orutinoside, dopamine, N-acetyl serotonin, and rutin, has been reported in the plant. They found higher content of polyphenols, flavonoids, total dietary fibre, insoluble dietary fibre, lignin, hemicellulose, cellulose, lipids, proteins, and minerals. Objective: The prime objective of the current study is to validate and highlighting the medicinal and nutritional importance of Musa acuminata. Methods: A literature review has indicated the use of Musa acuminata in the treatment of various diseases such as fever, cough, bronchitis, dysentery, allergic infections, sexually transmitted infections, and some non-communicable diseases. The reported pharmacological activities of Musa acuminata include antioxidant, antidiabetic, immunomodulatory, hypolipidemic, anticancer, and antimicrobial especially anti-HIV activity. Results: Pharmacological investigations support the traditional importance of the medicinal plant and probably support the folk uses of Musa acuminata by the indigenous people to treat and heal many infections and diseases. However, individual bioac tive constituent(s) from different parts of this plant need further investigations to confirm various pharmacological claims and to explore the potential of Musa acuminata in the development of drugs and use in functional foods. Conclusion: A comprehensive assessment of the biological activities of Musa acuminata is included and possible mechanisms and phytochemicals involved have also been correlated to provide effective intervention strategies for preventing or managing diseases