Introduction: Hashimoto__ampersandsignrsquo;s Thyroiditis (HT) is a frequently observed autoimmune thyroid disease and the commonest cause of hypothyroidism. Although the association of hypothyroidism with cardiovascular risk is a well-documented fact, it is still not clear as to whether thyroid autoimmunity is an independent risk factor for atherosclerosis, a cardiometabolic risk factor. Objective: In this study, we attempted to elicit the probable association of Anti __ampersandsignndash;Thyroid peroxidase (Anti-TPO) antibodies with cardiometabolic factors (insulin resistance and dyslipidemia) in patients. Methods: In this observational study, sixty-five healthy controls and sixty-eight HT patients were enrolled. Serum concentrations of TSH, FT4, FT3, (Anti-TPO), Total Cholesterol (TC), Triglycerides (TG), HDL-Cholesterol (HDL-C), Very Low-Density Lipoprotein (VLDL), Fasting Blood Glucose (FBG) and Fasting Insulin levels were measured. LDL-Cholesterol (LDL-C), HOMA-IR and Atherogenic Index of Plasma (AIP) were calculated. Results: There was a significant increase in TC, TG, LDL, VLDL, AIP, Fasting Insulin and HOMA-IR among the HT group (P __ampersandsignlt; 0.001) compared to healthy controls. Despite a significant positive correlation between Anti-TPO antibodies and TC, LDL, Fasting Insulin, HOMA-IR, Anti-TPO was found to be independently associated with AIP as revealed in Regression analysis, which unequivocally demonstrates the cardiovascular risk in HT. Conclusion: The findings of the present study point to the implication of thyroid autoimmunity in insulin resistance and dyslipidemia, independent of thyroid function in patients with HT. Thus, the assessment of lipid profile variables and insulin resistance possess value in the treatment and management of HT patients.