Background: Osteoarthrosis (OA) is defined as a degenerative condition of the synovial joints. OA of the knee is ranked as one of the most significant causes of disability among the elders. It is a common disorder of cartilage degradation, synovial inflammation, osteophyte formation, thinning of joint space and subchondral sclerosis. Methods: 219 participants were allocated into three groups multidirectional wobble board lateral step-up exercise group (MD), unidirectional wobble board lateral step-up exercise group (UD) and control group. All the participants__ampersandsignrsquo; basic subjective data, clinical measurements including the age, gender, body mass index (BMI) and joint position sense were measured. Data were analyzed with a paired t-test, unpaired t-test and ANOVA. Results: This study shows both the unidirectional wobble board exercise group(UD) and multidirectional wobble board exercise group(MD) showed a better reduction in mean test angle of joint position sense in OA knee participants than the control group but multidirectional wobble board exercise group(MD) was better than unidirectional wobble board exercise group (UD). The longer 4 weeks duration was more beneficial than the shorter 2 weeks of weight-bearing wobble board protocol. Conclusion: This study proved that the multidirectional wobble board lateral step-up exercise is more beneficial than unidirectional wobble board lateral step-up exercise in OA Knee.