Kaposi sarcoma (KS) is a kind of cancer that is widespread all over the world. This is for the first time discovered by Hungarian physician and dermatologist Moritz Kaposi in 1872 as a skin tumor. The name Kaposi sarcoma was coined to honour of the discoverer. Kaposi sarcoma is caused by the Kaposi sarcoma herpesvirus (KSHV). This is soft tissue cancer of blood vessels and lymphatic system developing purplish-red coloured lesions mostly in mouth, face, nose, genitals, and the lower extremities. The KSHV is easily transmitted either sexually or via the act of parturition vertically. There are 4 types of Kaposi__ampersandsignrsquo;s sarcoma distributed globally such as chronic or European, endemic or African, transplant-associated or iatrogenic and AIDS-related or epidemic. Italians using topical steroids are more prone to have this type of cancer. The KSHV has been isolated in almost all cases of Kaposi__ampersandsignrsquo;s sarcoma cancer. KS is composed of spindle shaped cells and inflammatory mononuclear cells. These cells grow faster and survive for a longer period of time. The various stages of Kaposi__ampersandsignrsquo;s sarcoma are maculonodular stage, infiltrative stage, florid stage and disseminated stage. The KSHV has also been found to be associated with two other lymphoproliferative diseases such as primary effusion lymphoma (PEL) and multicentric Castleman__ampersandsignrsquo;s diseases. Kaposi__ampersandsignrsquo;s sarcoma is an outcome of viral infection. As this is not a curable disease, it can often be treated for many years. And, public awareness about KS can only save the lives properly. However, currently, the drug used to treat Kaposi__ampersandsignrsquo;s sarcoma are thalidomide, bevacizumab, and sirolimus.