Introduction: Pertussis (Whooping Cough) is a serious disease having the highest incidence and severe, potentially life-threatening complication rates among young infants. Death due to pertussis occurs mostly in infants of __ampersandsignlt; 3months of age. Unfortu nately, infants are unable to build their protection until they get vaccinated at 6-8 weeks of birth. Thus they remain unprotected in the first months of life and during this time they are at the greatest risk of contracting the disease and falling very sick. On one hand, the babies don__ampersandsignrsquo;t have immunity of their own and on the other hand, they come in contact with individuals in the older age group whose immunity has decreased over time and get infected. Immunization strategy to a particular group such as infant caregivers and family members (Cocooning Strategy) achieved some success. Pertussis vaccination to pregnant ladies protects infants under the passive and active transplacental transfer of maternal antibodies giving protection to the infants till they build their immune system through vaccination. Studies demonstrate that acellular pertussis vaccination ensures safety both for mother and infant. The efficient transplacental transmission of maternal pertussis antibodies effectively prevents pertussis in young infants during the first months of life. Objective: A study reported higher pertussis antibody concentrations in the period between birth and administration of the first dose of vaccine in infants born to mothers immunized with Tdap vaccine during pregnancy. Besides Cocooning and neonatal immunization, vaccination of pregnant women offers hope to prevent the incidence of pertussis in infants of __ampersandsignlt; 3 months of age. The best timing of pertussis vaccination in pregnancy is yet to be determined. Conclusion: The American College of Obstetricians and Gynaecologists (ACOG) recommends administering the tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine (Tdap) to pregnant women during each pregnancy in the 27-36 week gestational period or with at least 2 weeks before the expected date of delivery.