Introduction: Appendicitis is the most common pathological condition of the appendix. Appendectomy is a surgical procedure to remove the appendix constituting 40% of all abdominal surgeries performed in the world. Objective: The present study was conducted to analyze the histopathological profile of surgically resected appendix and create a clinical profile that may help in better diagnosis and management of appendicitis. Methods: Histopathological records of 616 resected specimens of the appendix were reviewed retrospectively to correlate clini cal profile, histopathologic findings and unusual findings. Results: The study included 616 specimens of appendix out of which 371(60.22%) specimens were of males and 245(39.77%) specimens were of females. The most commonly affected age group was of 21 to 30 years with 285(45.96%) samples. On histopathological examination, 95 (15.3%) samples were of acute appendicitis. 314 (50.6%) samples were of chronic appen dicitis, 155 samples (25%) had an acute on chronic impression and 52 (8.3%) samples had the acute suppurative impression. 1.1% of the samples showed perforation with slight female preponderance. 1 specimen of carcinoid tumour, 2 specimens with granulomatous lesions,1 specimen with parasitic infestation and 1 specimen of gangrenous appendicitis was found. All cases presented with pain in the abdomen clinically. Conclusion: Our study concludes that whenever young patients present with a symptom of non-specific abdominal pain, ap pendicitis should be considered as a possibility. Histopathological analysis confirms the diagnosis of appendicitis and identifies the need for further follow-up.