Background: In a haemato-oncological setting, a long term drug delivery route is very much needed. Peripherally inserted central catheters (PICC) are used for this purpose. Objective: This study was aimed to observe the complications associated with PICC insertion. Methods: This was a prospective observational study over one year in the Department of Medical Oncology at Khyber Superspecialty hospital, Srinagar, India. A total of 200 subjects participated in this study. The data was collected concerning disease, catheter dwell time, and complications. USG guided or unguided PICCs were inserted. The position of PICC was confirmed. PICC line was then fixed with stat lock. Complications associated with this procedure were noted. Out of 200 patients enrolled, 60% (120/200) were males and 40% (80/200) were females. Unguided PICC was inserted in 90% and USG guided in 10% of participants. Unguided procedures were done in 2 minutes with an average blood loss of 2 ml. Results: Around 5% reported pain within 24 hours and 2.5% reported fever beyond 24 hours. The average dwell time for a single PICC was 5 months. 35% developed line fracture which was correctable. Only 3% developed serious complications viz; CABSI (Catheter-associated bloodstream infections) in 2.5% and thrombosis in 0.5%. Conclusion: PICCs are safe and can be used for extended periods. Unguided PICCs were placed in most of the participants without any major complications. From this study, it appears that PICCs are safe to use with low thrombotic and infectious complications. The most common complications were line fracture, pain and fever.