Introduction: In recent years, neural system study has become a fruitful approach in diagnosing neurological diseases. Brain signals being at very low potentials pose a difficulty to study them. Fault analysis of those signals may lead to improper diagnosis of the diseases. So, amplification of the brain signal is required. The amplified signal is prone to noise. Objective: To meet the limitations of the neural acquisition system a novel design for ultra-low noise neural recording amplifier is discussed in this paper. Methods: Characterization of transistors is the technique used to design the amplifier. The amplifier is designed in a standard 0.18__ampersandsignmicro;m Complementary metal oxide semiconductor process (CMOS). Results: The amplifier achieved a gain of 43.6dB with a total power consumption of 26.29__ampersandsignmicro;W and input-referred noise of 313.6pVrms.