Introduction: Suicide is complex interactions of mood disorders and which has been around for as long as since the birth of human society and is one of the leading causes of death in India and all around the world. Adrenal glands are a pair of endo crine glands and target structure of the Hypothalamic Pituitary Adrenal axis and stress system. Stress plays an important role in affecting adrenal gland structure and function which may have a connection with suicidal behaviour in depressed individuals. Objective: To analyze the morphometric changes in length, breadth, thickness and weight of human adrenal glands in hanging and poison death autopsy cases in different age groups. Methods: Sample Size: 186 adrenals from 93 cadavers (52 hanging and 41 poison cases). Study Design: Analytical __ampersandsignndash;observational Study. Study setting: The samples were collected from Post mortem centre at Sri Venkateswara hospital, Chittoor district and divided into three age groups like 20-30, 30-40, 40-50 years. A study was done at Peoples Education Society Institute of Medical Sci ences and Research, Kuppam. Chittoor District. The length, breadth, thickness and weight of the samples were measured and results were compared between hanging(sudden death) and poison death(delayed death) autopsy cases. Sampling Technique: Simple random sampling Inclusion Criteria: Both genders of Hanging and poison death cases,3 Age group 20-30 years, 30-40 years and 40-50years and time of autopsy in between 12-24 hours after death were included. Exclusion Criteria: The Adrenal abnormalities, Chronic debilitating illness, Decomposed autopsy cases, Pregnant women, Ac cident cases, Burns cases, Age group less than 20 and more than 50years, Commence of autopsy less than 12 hrs and more than 24 hrs were excluded. Results: In our study, we found that the length and breadth of right and left adrenal glands were significantly different in the 31- 40 years group when compared to the other two groups. There was a significant difference in thickness of the right adrenal gland when compared with the left adrenal in the group of 31-40 years. When compared to the weight of right adrenals, there was a significant difference in the weight of the left adrenal in the age group of 31-40 years. Conclusion: The length, breadth, thickness and weight of the left and right adrenal glands were significantly different in the 31- 40 years age group and the values of parameters in hanging cases were high compare with poison cases in overall estimation.