Background: Pulmonary consolidation is a common clinical entity that may arise due to infections or malignancy. Objective: To determine the clinical role, safety, diagnostic accuracy and complications of CT guided lung biopsy in the evalua tion of non-resolving lung consolidation. Methods: A retrospective review of all CT guided PTNB (percutaneous transthoracic needle biopsy) at a tertiary care hospital was performed from February 2018 to January 2020 for non-resolving consolidations. Radiologic, Histopathologic and Microbio logical results were obtained and clinical follow up was performed. Results: Over 2 years, twenty-one out of 475 consolidations (4.4%) were subjected to PTNB. The mean age was 64.04 __ampersandsignplusmn; 5.12 years. Male: Female ratio was 4:1. The final diagnosis was established in 20 out of 21 (95.23%). Malignancy was detected in 15 out of 21 (71.42%). Tuberculosis was detected in 2/21 (9.52%). Lymphoma was detected in (14.28%). Procedure-related complications were rare and no procedure-related death was noted. Pneumothorax was seen in 2/21 (9.5%) patients. Mild hem optysis was seen in 3/21 (14.2%) patients. Conclusion: Non-resolving lung consolidation can be safely and effectively evaluated with CT guided percutaneous needle biopsy. The diagnostic yield is high and the procedure is safe.