Now that we have entered the postgenomic era, the association between the potential protective role of nutrients and periodontal diseases is well established. It is likely to know that interactions between the genotype and diet are important in determining periodontal disease risk. A change in dietary pattern represents a promising approach in reducing the risk of aging by modulating gene expression. One of the most practical applications of nutritional modulation of chronic disease is that they regulate the expression of key inflammatory genes. Nutrigenomics is a branch of nutritional genomics focusing on identifying and understanding molecular- level interaction between nutrients and other dietary bioactives with the genome. New techniques and knowledge from the Human Genome Project named as nutrigenomics are currently combined with already established scientific disciplines such as pharmacogenomics and toxicogenomics. This manuscript reviews the evidence for nutritional exposures in the etiology and makes recommendations for daily nutritional intake for periodontal prevention / treatment regime.