Introduction: Many recent studies are done on the efficiency of natural components for the treatment of diabetes, it has been found that many antioxidant components are present. Objective: The present study aims to study and identify the target sites which can be used as targets with appropriate ligands for diabetics. Methods: Structure-based drug design was performed and protein docking was done with known ligands. Analyzing the receptor-ligand interaction between the active site of the protein and the chemical molecules was performed. Results: All the compounds that satisfy the absorption, distribution, metabolism, excretion and toxicity (ADMET)properties are more favourable to bind with receptor. Discovery Studio tool was used to find the least energetic compound and based on the docking parameter against the receptor-ligand complex and which notified us of the acceptors and the donors in the analysis portion. from the study, we analysed that these components which contain bioactive compounds can be used in medical research. Nitenin showed a good dock score of 47.404 and can inhibit the overexpression of the CD62E gene. Conclusion: The finalized complex of Nitenincompound can be used for further medical studies in the preparation of drug molecule against diabetes. The docking study reveals that the antioxidant components that are present can be used in the treatment of diabetes.