Introduction: Cefpodoxime is a safe, short course, effective, semi-synthetic, third-generation cephalosporin available for use as a prodrug known as Cefpodoxime proxetil and is recommended for treating sinusitis, otitis media, urinary tract infection, respira tory tract infections (upper and lower), skin infections, and soft tissue infections. It is available both in the form of branded prod ucts and generic products where both have been seen to have different quality, physicochemical, and stability characteristics. Objective: To explore the quality attributes of a branded cefpodoxime proxetil product and five different generic cefpodoxime proxetil products available in the Indian market. Methods: The present exploration involved investigating the quality attributes (Assay determination and Impurity testing), phys icochemical test (Physical appearance of tablets, Packaging and labelling of tablets, Tablet diameter and thickness, Weight variation test, Friability Test, Hardness test, Disintegration test, and In vitro dissolution study), and accelerated stability study (1 month, 3 months, and 6 months under temperature 40__ampersandsigndeg;C __ampersandsignplusmn; 2__ampersandsigndeg;C and humidity 75% __ampersandsignplusmn; 5% RH) of a branded cefpodoxime proxetil product and five different generic cefpodoxime proxetil products available in the Indian market as per the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) guidelines (Q2 and Q3) and the United States Pharmacopeia (USP) guidelines. A comparison between the branded product and the generic products has been made in terms of the quality attributes. Results: All the generics and the branded cefpodoxime proxetil tablets were found to be within the acceptable range. Conclusion: The study will open new doors of analysis of pharmaceutical quality assurance and provide avenues for both branded products and generic products in maintaining the quality attributes regularly