Background: Osteoarthritis (OA) of the knee is the most common type of arthritis and the leading cause of disability that impacts the elderly and middle-aged worldwide. Maitland mobilization reduces pain, improves range of motion and functional disability. Conventional treatment reduces pain and improves the range of motion of the knee joint. Objective: To study the effects of Maitland mobilization and Conventional treatment on Pain, Range of Motion and function dis ability inpatient with osteoarthritis with a knee. Method: 72 subjects (36 in each group), Interventional study Sample and Sampling Method: 72 subjects were randomly se lected and assigned in two groups, Group A (Maitland mobilization) and Group B (Conventional) in equal numbers. A total num ber of 72 subjects were included in the study as per the inclusion and exclusion criteria. Kellegren and Lawrence grade 1 and 2 radiographic evidence of osteoarthritis, BothGenders, Age between 40 to 60years, Knee osteoarthritis with duration __ampersandsignge; 1 year, Average knee pain __ampersandsignge;3 on Visual AnalogScale,Subjects with Unilateral knee joint, Tibiofemoral and Patellofemoral knee joint, Tenderness over kneejoint. Acute exacerbation in or around kneejoints, Traumatic injury to knee joints within 6 months of study, Any surgical intervention to the kneejoints, Intra-articular steroid injection in knee joints within 3months, Subject with Psychiatric disorders/Illness, Peripheral vascular disease, Tumors/malignancies/infections associated with kneejoint. lower limb metallic implants, Impaired thermal sensation over the knee. Results: Results showed statistically significant improvement in both groups for VAS, ROM and functional disability by using student__ampersandsignrsquo;s Paired and unpaired t-test. Group A showed more significant improvement than Group B. Conclusion: In conclusion, Maitland Mobilization and Conventional therapy are more effective than conventional treatment alone in relieving pain, improving range of motion and functional well-being in subjects with knee osteoarthritis.