Introduction: Postpartum depression (PPD), a type of mood disorder, is the most frequently noted morbidity during the post partum period. Objective: To investigate the prevalence and assess risk factors of postpartum depression symptom among post-partum mother in Al-Madinah, Saudi Arabia. Methods: This cross-sectional study was conducted on a population of 360 post-partum mothers delivered in the hospitals in Al-Madinah city, from January to February 2019 in Al-Madinah, Saudi Arabia. Data were collected using the Edinburgh Postnatal Depression Scale (EPDS). The data were analyzed with Version 22.0 of the Statistical Package for Social Science. Descriptive statistics, Spearman correlation, Mann Whitney test and Kruskal Wallis test were used. Results: The prevalence of post-partum depression PPD among post-partum mothers was 23%, with a mean score of 9.0__ampersandsignplusmn;5.0. Post-partum depression was significantly higher among mothers who delivered at the house, those who had depression during a previous pregnancy and those who had a family history of PPD. (p__ampersandsignlt;0.05). Conclusion: Post-partum depression was found in one-third of the post-partum mothers who included in the study. Women who had previously been diagnosed with PPD reported a family history of PPD were at particularly high risk for postpartum depres sion. To prevent and treat postpartum depression, special care should be provided to women reporting risk characteristics.