Background: Gallstones are common in Indian population.Laparoscopy requires longer and steeper learning curve and proper patient selection. Patients belonging to lower socioeconomic group usually present late, develop one or the other complications of cholelithisis prior to surgery and expected to have higher conversion rate, per-operative and post-operative complications. Aims: To study safety and efficacy of laparoscopic cholecystectomy in patients of cholelithiasis by comparing with results of open cholecystectomy in terms of use of post-operative analgesia, operative Time, post-operative hospital stay, morbidity and mortality. Material and Method: Patients operated for gallbladder stone betweenJanuary 2013 and August 2015were retrospectively analyzed in terms of demographic profile, clinical presentation, procedureperformed and its findings, operating time, conversion rate, postoperative pain and analgesic requirement, postoperative hospital stay and complication. Results: Cholecystectomy was performed in 630 patients between January 2013 and August 2015. 368 patients were operated laparoscopically and 232 patients by open method. It comprises of almost 25 percent of major operations performed during this period, 75.8% were females and 9 of them were less than 15 years of age. The mean operating time during 2013 for laparoscopic and open Cholecystectomy was 68.37 minutes and 66.20 minutes, decreased to 46.27 minute and 53.33 minute during 2014-15, respectively. Intraoperative cholangiography was not required in any case. Conclusion: Cholelithiasis is relatively common in India even in lower socio-economic group. Dietary habits and obesity do not appear as contributing factor.Laparoscopy has better visibility, access and operating time than open cholecystectomy. Complications rate is negligible even in difficult gallbladders, if proper planning is done with ultrasonography and liver function test 24 hours prior to surgery.